A promising alternative is electrospinning aqueous dispersions of water insoluble polymers like polystyrene or polyacrylates 8, 9. Nanofibers of watersoluble polymers via foam electrospinning. A study of the composition and structure of water soluble fractions of the samples after coextrusion showed the presence in them of up to 18 wt% chitosan, usually insoluble in water at neutral ph values. Dai m, jin s and nugen s r 2012 watersoluble electrospun nanofibers as a method for onchip reagent storage biosensors 2 38895 crossref dewaal c s 2007 food protection and defense. China is the leading global consumer of synthetic water soluble polymers, accounting for more than half of global consumption. The polymer to compose the scaffold is spun simultaneously with a watersoluble template polymer that can be removed by extensive rinsing after production of the scaffold. The electrical conductivity of the solution is known to have an important role in the formation of nonbeaded nanofibers. Data were acquired for several solvents including water, dimethyl sulfoxide. Perhaps the most commonly used application for waterbased polymers is the fabrication of inorganic fibers. Electrospun water soluble polymer mat for ultrafast release of. Electrospinning watersoluble insoluble polymer blends. Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers. Electrospinning of aqueous ligninpolyethylene oxide. Electrospinning spinning of water soluble polymers.
The use of watersoluble polymers in electrospinning and. A study of the composition and structure of watersoluble fractions of the samples after coextrusion showed the presence in them of up to 18 wt% chitosan, usually insoluble in water at neutral ph values. Nanofibers of watersoluble polymers via foam electrospinning alina k. The solubility of curcumin was increased from zero to 7.
Crosslinking the fibers after electrospinning creates. The invention provides novel polymer nanofiber or microfiber mats or membranes and methods for their preparation via an aqueous, onestep polyelectrolyte complexation and electrospinning of complex coacervates. Many polymers that are soluble in other nontoxic solvents, such as water or ethanol, can also be dissolved in dmso. Pva with various degrees of hydrolysis dh88, 96 and 99. Inorganic precursors are usually salt that dissolves in water and ethanol. Applications for watersoluble nanofibers electrospintech. Shapes and properties of fibers can be tailored according to the demand of numerous applications including filtration, membranes, textiles, catalysis, reinforcement.
Wo2008022993a2 process for producing nano and mesofibres. Most of these materials are commonly used in electrospinning research and the range includes both watersoluble and nonwatersoluble polymers. Because ha is a water soluble polymer, its electrospinning in water is particularly interesting for obvious toxicity reasons. The following pie chart shows world consumption of synthetic watersoluble polymers. Among water soluble polymers, electrospinning of aqueous solutions of lignin with pva and cellulose nanocrystals have been reported. The nanofibers prepared from the renewable polymers can combine the excellent properties of the renewable polymer and nanofiber, such as high specific surface. Oct 31, 2012 ultrathin fibers based on polyvinyl alcohol, polyacrylic acid, and their mixed composites were prepared. To facilitate electrospinning into fibers, watersoluble polymers are often added to form a precursor mixture. Acppla nanofibers and watersoluble drugcontaining acppla nanofibers by electrospinning. In order to produce structures that are as close as possible to those of natural tissues, electrospinning of ha, is highly desirable.
Browse sigmaaldrich s water soluble polymers to find products in dextran, poly acrylic acid sodium salt, poly ethylene glycol, polymethylacrylic acid sodium. A machine has been constructed capable of electrostatically spinning electro spinning a wide range of polymer solutions for the production of nano and micrometer diameter polymer fibres and fibrous nonwovens. Perhaps the most commonly used application for water based polymers is the fabrication of inorganic fibers. The use of large amounts of environmentally unfriendly, toxic, and flammable organic solvents in electrospinning of polymers puts demand on the development of new methods and formulations for making water stable hydrophobic nanofibers from water soluble precursor solution.
Schoolaert, ella, paulien ryckx, jozefien geltmeyer, et al. It was concluded that electrospinning is a useful technique for the improvement of the poorlysoluble drugs such as curcumin. The first successful preparation of nanofibers of a polyampholyte ncarboxyethylchitosan by electrospinning was achieved by adding a nonionogenic watersoluble polymer to the spinning solution. Electrospinning and crosslinking of watersoluble polymers. Ultrathin fibers based on polyvinyl alcohol, polyacrylic acid, and their mixed composites were prepared. Electrospun amorphous solid dispersions of poorly water.
This article reports on direct electrospinning of watersoluble cellulose acetate wsca and cellulose diacetate cda onto a nonconductive synthetic polymer. Laboratory of bioactive polymers, institute of polymers, bulgarian academy of sciences, 11 so. The influence of the solution characteristics and fiberspinning parameters on the structure and properties of the nonwoven materials was found. This method can be simplified further if a solvent which dissolves both polymers is used. Electrospun watersoluble polymer nanofibers for the. T7 to be encapsulated and preserved in water soluble nano. Pdf electrospun water soluble polymer mat for ultrafast. Watersoluble electrospun nanofibers as a method for on. The bacteriophage t7 was added to mixtures of polyvinylpyrrolidone and water and electrospun onto a grounded plate. Water soluble polymers of the range of water soluble polymer that are available, some of the most common ones that have been used in the electrospinning process are polyvinylpyrrolidone pvp 21,23, polyvinyl alcohol pva 24,25, polyacrylic.
New polymers for needleless electrospinning from low. Comparison of two electrospinning processes in obtaining finer polymer nanofibers. The present invention relates to a process for producing polymer fibres, especially nano and mesofibres, by the electrospinning process, in which a colloidal dispersion of at least one essentially water insoluble polymer and of at least one nonionic surfactant, if appropriate further comprising at least one water soluble polymer, is electrospun in an aqueous medium. The polymers include biodegradable hydrophilic polymers, hydrophobic poly mers and amphiphilic polymers. Apr 28, 2010 the electrical conductivity of the solution is known to have an important role in the formation of nonbeaded nanofibers. The watersoluble nature of fdma presents a great challenge, because any contact with water can destroy the fibrous structure immediately, thereby severely limiting the application of this polymer. Electrospun water soluble polymer mat for ultrafast.
Do read laboratory safety considerations before starting your experiment. Electrospinning water solubleinsoluble polymer blends daria w ehlage, robin bo ttjer, timo grothe and andrea ehrmann faculty of engineering and mathematics, bielefeld university of applied. Request pdf the use of water soluble polymers in electrospinning and their application fields with the increasing dominance of the electrospinning process, the diversity of materials that. Electrospun water soluble polymer mat for ultrafast release. Electrospinning of blends is a variation of this technique which uses the fact that polymers are generally immiscible with each and can phase segregate without the use of surfactants. In this paper, polyacrylonitrile pan nanofiber mats were blended with eight watersoluble polymers to test which blends are spinnable and result. Natural, water soluble polymers are an attractive alternative, as they are readily soluble in aqueous media because of their hydrophilic.
Watersoluble copolymer compositions of polysaccharides. Promoting the encapsulation efficiency of watersoluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the watersoluble drug molecules and hydrophobic polymers solution. Renewable polymers have attracted considerable attentions in the last two decades, predominantly due to their environmentally friendly properties, renewability, good biocompatibility, biodegradability, bioactivity, and modifiability. Electrospun polyimide pi nanofibers are of particular interest for a variety of applications due to their extraordinary. The possibility of using solidstate reactive extrusion for graft copolymerization of polysaccharides has been revealed. Direct electrospinning of cellulose acetate onto polyurethane sheet. Methods for preparing solid solutions kneading technique in this method, carrier is permeated with water and transformed to paste. Electrospinning of aqueous ligninpolyethylene oxide complexes.
Khan department of chemical and biomolecular engineering, north carolina state university motivation materials and methods results conclusions future work 1 compressed gas pumps through fritted container 2. The invention relates to a process for the preparation of polyamide nanofibers by electrospinning, wherein the process is a multinozzle electrospinning process with the use of a multinozzle device or a nozzlefree electrospinning with the use of nozzle free device, comprising steps wherein a high voltage is applied, a polymer solution comprising a polymer and a solvent is fed to the multi. Engineering of biohybrid materials by electrospinning. Us10428444b2 us15725,465 us201715725465a us10428444b2 us 10428444 b2 us10428444 b2 us 10428444b2 us 201715725465 a us201715725465 a us 201715725465a us 10428444 b2 us10428444 b2 us 10428444b2 authority us united states prior art keywords method electrospinning polymer polyanion polycation prior art date 20161011 legal status the legal status is an. Jan 20, 2010 polyvinyl alcohol pva is a highly hydrophilic, nontoxic and biocompatible semicrystalline polymer with excellent properties such as strength, water solubility, gas permeability and thermal. Effects of molecular weight and solution concentration on. Us10428444b2 polymer nanofibers from electrospinning of. Effects of molecular weight and solution concentration on electrospinning of pva by jing tao a thesis submitted to the faculty. Polyvinylalcohol of low molecular weight was found.
The first successful preparation of nanofibers of a polyampholyte ncarboxyethylchitosan by electrospinning was achieved by adding a nonionogenic water soluble polymer to the spinning solution. Browse sigmaaldrich s water soluble polymers to find products in dextran, poly acrylic acid sodium salt, poly ethylene glycol, polymethylacrylic acid sodium salt, polystyreneslfonic acid sodium salt, pullulan. It should be mentioned that using dmso to dissolve watersoluble polymers can also be of technological interest for blends of the respective polymers with nanoparticles that are oxidized in aqueous solutions, such as several magnetic nanoparticles. Natural, watersoluble polymers are an attractive alternative, as they are readily soluble in aqueous media because of. Nanofibers of water soluble polymers via foam electrospinning alina k. Therefore, electrospinning of aqueous solutions is more preferable.
The process does not require the use of coagulation chemistry or high temperatures to. For training on electrospinning, it is advisable to use watersoluble polymer as this would eliminate exposure to otherwise toxicflammable solvents. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and. Water soluble nanofibers can provide an ideal reagent format for microfluidics. Water soluble polymers polymer standards sigmaaldrich. Electrospinning is from the academic as well as technical perspective presently the most versatile technique for the preparation of continuous nanofi bers obtained from numerous materials including polymers, metals, and ceramics. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultrafast dissolution in water based media. A watersoluble carrier polymer allows aqueousbased environmentfriendly electrospinning process and watersoluble drug loadings in the topical nanomats. Dehydration during the electrospinning process occurs over very short periods of time resulting in an almost instantaneous transformation from an enzyme in solution to a dried enzyme trapped in a polymer and sucrose matrix. Electrostatic spinning electrospinning, es was applied to prepare donepezil hcl loaded nanofibers as a poten tial orally dissolving dosage form. Different studies have focused on the use of modified ha to allow a crosslinking step after electrospinning, involving a modification step of ha before its. Among water soluble polymers, electrospinning of aqueous solutions of lignin with pva and cellulose nano. Electrospinning shares characteristics of both electrospraying and conventional solution dry spinning of fibers. A water soluble carrier polymer allows aqueousbased environmentfriendly electrospinning process and water soluble drug loadings in the topical nanomats.
Curcumin was found practically insoluble in distilled water and ph 1. It was shown that interpolymer complexes could be used as spinning compositions for electrospinning on needlefree nanospider equipment of fibers and nonwoven materials. Electrospinning parameters and fibres diameters are indicated in table 1. To create this structure, the polymer matrix needs to be a sufficiently fluid. Watersoluble polymers, synthetic chemical economics. It is seen that the mmt and ag nanoparticles are distributed uniformly in nanofibers.
In dispersion, electrospinning a water soluble polymer is used in small amounts to support the fiber formation process as shown schematically in figure 7. Preparation of nanofibers with renewable polymers and. It was concluded that electrospinning is a useful technique for the improvement of the poorly soluble drugs such as curcumin. Most watersoluble polymers have the inherent limitation of resulting in watersoluble nanofibers, and a tedious chemical crosslinking step is required to reach stable nanofibers. If these mechanical and biocompatible properties are combined with the high surfacetovolume ratios of fibers, the hydrogel can be used as an efficient support material both for enzymes and for immobilization of. Use of watersoluble polymers for electrospinning processing. Copolymers of acrylic acid with, in particular, 2acrylamido2methylpropanesulphonic acid ampsa.
To facilitate electrospinning into fibers, water soluble polymers are often added to form a precursor mixture. Waterborne electrospinning of polynisopropylacrylamide by. Electrospinning fabrication and characterization of water soluble polymer montmorillonitesilver nanocomposite nanofibers out of aqueous solution. The polymer to compose the scaffold is spun simultaneously with a water soluble template polymer that can be removed by extensive rinsing after production of the scaffold. Electrostatic spinning electrospinning, es was applied to prepare donepezil hcl loaded nanofibers as a potential orally dissolving dosage form. Request pdf the use of watersoluble polymers in electrospinning and their application fields with the increasing dominance of the electrospinning process, the diversity of materials that. Research article studies on improvement of watersolubility. Electrospinning in water and in situ crosslinking of. Trehalose and magnesium salts were added to the mixtures to determine their effect on the infectivity of the bacteriophage following electrospinning and during storage. The primary water dispersible polymer is a sulfonated copolyester with an average 1. Tests on electrospinning polymers from dmso, however, are reported scarcely.
Electrospun water soluble polymer mat for ultrafast release of donepezil hcl. It should be mentioned that using dmso to dissolve water soluble polymers can also be of technological interest for blends of the respective polymers with nanoparticles that are oxidized in aqueous solutions, such as several magnetic nanoparticles. Waterborne electrospinning of polynisopropylacrylamide by control of environmental parameters. The electro spinning process is of great utility in the manufacture of nonwoven fabrics for a variety of applications including tissue engineering.
The nation is also the fastestgrowing market for these polymers and will account for the bulk of consumption growth during 534756. A method of electrospinning water dispersible polymers using a water soluble polymer as the template has been determined. New polymers for needleless electrospinning from lowtoxic. Coaxial electrospinning with sodium thiocyanate solution for preparing polyacrylonitrile nanofibers. To date, there is only little information available about the use of soluplus in electrospinning and other nanofabricationbased methods. Preparation of ultrafine watersoluble polymers nanofiber mats via. Cd are soluble in water, and thus cannot be used directly as substrate for drug release because of prematurely aqueous dissolution in physiological conditions. Polyimide nanofibers by green electrospinning via aqueous. To facilitate electrospinning into fibers, watersoluble polymers are. Soluplus is a watersoluble copolymer with the average molecular weight ranging from 90,000 to 140,000 gmol, and it is capable of solubilizing poorly watersoluble drugs.
With increasing toxicity and environmental concerns, electrospinning from water, i. The average diameters varied between 268 nm and 1,607 nm depending on the solutions and parameters used. Electrospinning watersolubleinsoluble polymer blends aims press. Electrospinning can be used to produce nanofibers of pva with various architectures. Electrospinning is carried out to form precursor fibers. The sodium polystyrene sulphonate or sodium polyvinyl sulphonate type,which are highly anionic polymers of low molecular weight. The principal characteristics of the solutions and parameters of a stable electrospinning process for fibers and nanofibrous materials were found. Electrospinning of water solutions of different polymers were performed in order to fab ricate a consistent and removable web on the collector with ultrafast dissolution in water based media. Us20120145632a1 electrospinning of polyamide nanofibers. In addition, porous hydrophilic nano brous membranes have been shown to provide better wound healing performance than hydrophobic ones. Watersoluble copolymer compositions of polysaccharides for. Watersoluble electrospun nanofibers as a method for onchip. Watersoluble nanofibers can provide an ideal reagent format for microfluidics.
Waterborne electrospinning of polynisopropylacrylamide. Performances of a portable electrospinning apparatus. China is the leading global consumer of synthetic watersoluble polymers, accounting for more than half of global consumption. In most cases, the large surfacetovolume ratio and correspondingly large contact area with the environment is utilized. The following pie chart shows world consumption of synthetic water soluble polymers. Electrospun watersoluble polymer nanofibers for the dehydration. Preparation of polyelectrolytecontaining nanofibers by. Electrospun amorphous solid dispersions of poorly watersoluble drugs. Pdf electrospinning watersolubleinsoluble polymer blends. Electrospinning fabrication and characterization of water.
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